A recent study in Science Advances reports chemical traces in ancient teeth that suggest people in what is now Sulawesi were using betel nut tens of thousands of years ago—well before scholars previously thought. That shift in timing reshapes how researchers view early human experimentation with psychoactive substances and hints at long-running cultural knowledge about mind‑altering plants.
Archaeologists working at the cave site of Leang Bulu Bettue recovered molars with unusually deep wear and chemical markers consistent with the psychoactive alkaloid arecoline, the active compound in the betel nut. The teeth belong to a hunter‑gatherer individual dated to roughly 16,000–25,000 years ago, making these among the oldest direct signs of intentional consumption of a mind‑altering plant.
What the evidence shows
Researchers combined microscopic analysis of tooth wear with chemical testing to reach their conclusions. The deep grooves on the molars indicate repeated mechanical action—sucking or chewing—while residue analysis detected traces matching arecoline. Together, the two lines of evidence point to deliberate, habitual use rather than accidental exposure.

Another individual found in a nearby cave and dated to about 7,000 years ago displayed similar dental patterns, suggesting the practice persisted in the region over millennia rather than appearing as a one‑off experiment.
- Location: Leang Bulu Bettue cave, Sulawesi, Indonesia
- Estimated age: approximately 16,000–25,000 years for the older individual
- Chemical marker: arecoline, associated with betel nut
- Physical evidence: distinctive deep grooves on molars consistent with prolonged sucking or chewing
- Broader implication: cultural transmission of substance use across generations
Why this matters now
Placing intentional psychoactive use this far back in prehistory changes timelines for how early humans explored plant chemistry and managed pain, social rituals, or other effects. It also adds a new layer to discussions about the long‑term impacts of such practices: modern betel nut chewing remains widespread across Asia and the Pacific and is linked to oral health problems and increased cancer risk.

The new findings offer a bridge between archaeological science and contemporary public‑health conversations. If people were regularly processing and consuming the nut thousands of years ago, it suggests deep cultural roots for a habit that still affects hundreds of millions today.
Limits and next steps
The study relies on a small number of skeletal remains and focused chemical signatures, so the results are compelling but not yet conclusive for all ancient populations. Further excavations, more residue analyses, and comparisons with other sites will be important to confirm how widespread the practice was and what roles it served—therapeutic, social, ritual, or some combination.
For now, the work stands as a reminder that human curiosity about altering consciousness is an ancient behavior, and that the consequences—both intended and unintended—have been part of our story for far longer than previously documented.
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